描述

PKR-IN-C16 是特异性蛋白激酶 (PKR) 抑制剂。PKR-IN-C16 能够抑制 PKR 的自磷酸化，PKR 在原代神经元细胞培养中诱导的翻译阻断可被 PKR-IN-C16 解除。

相关类别

信号通路 >> 其他 >> 其他

研究领域 >> 神经疾病

参考文献

[1]. Tronel C, et al. The specific PKR inhibitor C16 prevents apoptosis and IL-1β production in an acute excitotoxic rat model with a neuroinflammatory component. Neurochem Int. 2014 Jan;64:73-83.

密度

1.6±0.1 g/cm3

沸点

674.6±55.0 °C at 760 mmHg

分子式

C13H8N4OS

分子量

268.294

闪点

361.8±31.5 °C

精确质量

268.041870

PSA

98.91000

LogP

0.80

蒸汽压

0.0±2.1 mmHg at 25°C

折射率

1.851

危险品运输编码

NONH for all modes of transport

(8Z)-8-(1H-imidazol-4-ylmethylidene)-6,8-dihydro-7H-[1,3]thiazolo[5,4-e]indol-7-one

(Z)-8-((1H-Imidazol-4-yl)methylene)-6H-thiazolo[5,4-e]indol-7(8H)-one

8-(1H-Imidazol-4-ylmethylene)-6,8-dihydro-thiazolo[5,4-e]indol-7-one

(8Z)-8-(1H-Imidazol-5-ylmethylene)-6,8-dihydro-7H-[1,3]thiazolo[5,4-e]indol-7-one

C16 (PKR inhibitor)

7H-Thiazolo[5,4-e]indol-7-one, 6,8-dihydro-8-(1H-imidazol-5-ylmethylene)-, (8Z)-