简介：(+)-JQ-1 是一种 BET bromodomain 抑制剂,抑制 BRD4(1/2) 的 IC50 分别为 77 nM 和 33 nM。
(+)-JQ1物理化学性质：
密度 1.3±0.1 g/cm3
沸点 610.4±65.0 °C at 760 mmHg
分子式 C23H25ClN4O2S
分子量 456.988
闪点 322.9±34.3 °C
精确质量 456.138672
PSA 97.61000
LogP 4.49
外观性状 white to beige
蒸汽压 0.0±1.7 mmHg at 25°C
折射率 1.657
储存条件 2-8°C
水溶解性 DMSO: soluble20mg/mL, clear
(+)-JQ1详细介绍：
产品名称： [Perfemiker](+)-JQ-1,98%
英文名称： (+)-JQ-1
品牌： Perfemiker
CAS号： 1268524-70-4
纯度： 98%
详细描述： 创赛优选商城提供的(+)-JQ-1,98%为创赛科技出品的其它生化试剂,产品稳定,定制速度快,极大地方便了广大科研客户的使用需求。产品包装为100mg。查询关键词:其它生化试剂，1268524-70-4，(+)-JQ-1,98%，(+)-JQ-1，博飞美科，Perfemiker，上海，厂家现货。
(+)-JQ1参考文献：
[1]. Filippakopoulos P, et al. Selective inhibition of BET bromodomains. Nature. 2010 Dec 23;468(7327):1067-73.
[2]. Matzuk MM, et al. Small-molecule inhibition of BRDT for male contraception. Cell. 2012 Aug 17;150(4):673-84.
[3]. Peirs S, et al. Targeting BET proteins improves the therapeutic efficacy of BCL-2 inhibition in T-cell acute lymphoblastic leukemia. Leukemia. 2017 Feb 3.
[4]. T?gel L, et al. Dual Targeting of Bromodomain and Extraterminal Domain Proteins, and WNT or MAPK Signaling, Inhibits c-MYC Expression and Proliferation of Colorectal Cancer Cells. Mol Cancer Ther. 2016 Jun;15(6):1217-26.
[5]. Sahni JM, et al. Bromodomain and Extraterminal Protein Inhibition Blocks Growth of Triple-negative Breast Cancers through the Suppression of Aurora Kinases. J Biol Chem. 2016 Nov 4;291(45):23756-23768.
[6]. Nakamura Y, et al. Targeting of super-enhancers and mutant BRAF can suppress growth of BRAF-mutant colon cancer cells via repression of MAPK signaling pathway. Cancer Lett. 2017 Aug 28;402:100-109.
[7]. Bhattacharyya S, et al. Altered hydroxymethylation is seen at regulatory regions in pancreatic cancer and regulates oncogenic pathways. Genome Res. 2017 Nov;27(11):1830-1842.
[8]. Lv B, et al. Enhancement of adenovirus infection and adenoviral vector-mediated gene delivery by bromodomain inhibitor JQ1. Sci Rep. 2018 Aug 1;8(1):11554. doi: 10.1038/s41598-018-28421-x.
[9]. Huang X, et al. Targeting Epigenetic Crosstalk as a Therapeutic Strategy for EZH2-Aberrant Solid Tumors. Cell. 2018 Sep 20;175(1):186-199.e19. doi: 10.1016/j.cell.2018.08.058. Epub 2018 Sep 13.
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