包装储存 :Sealed and stored at 4℃，, away from moisture
生物活性 :Parecoxib Sodium (SC 69124A) is a highly selective and orally active COX-2 inhibitor, the prodrug of Valdecoxib (HY-15762). Parecoxib Sodium is a nonsteroidal anti-inflammatory agent (NSAID) and inhibits prostaglandin (PG) synthesis. Parecoxib Sodium can be used for the relief of acute postoperative pain and symptoms of chronic inflammatory conditions such as osteoarthritis and rheumatoid arthritis in vivo.
性状 :Solid
IC50 & Target[1][2]
COX-2
体外研究(In Vitro)
Parecoxib Sodium (0-200?μM; 24-48 hours) inhibits the cell proliferation of GBM cells in a dose-dependent manner in GBM cells.
Parecoxib Sodium (200?μM; 24-48 hours) results in a decreased migratory ability of U343 cells than PBS-treated group.
Medlife has not independently confirmed the accuracy of these methods. They are for reference only.
Cell Viability Assay
Cell Line: GBM cells: U251 and U343 cells
Concentration: 0 μM, 20 μM, 50 μM, 100 μM and 200?μM
Incubation Time: 24-48 hours
Result: Resulted in a slower BrdU incorporation rate of GBM cells including U251 and U343 cells.
体内研究(In Vivo)
Parecoxib Sodium (intraperitoneal injection; 2.5, 5.0 or 10 mg/kg; once a day; 21 days) does not affect locomotor activity in the elevated plus-maze test, and Parecoxib at 5 and 10 mg/kg shows higher levels of percentage of time spent in the open arms.
Medlife has not independently confirmed the accuracy of these methods. They are for reference only.
Animal Model: Naive adult male ICR mice, 15 weeks old and weighing 25-35 g
Dosage: 2.5 mg/kg, 5.0 mg/kg or 10 mg/kg
Administration: Intraperitoneal injection; 2.5, 5.0 or 10 mg/kg; once a day; 21 days
Result: Exerted an anxiolytic-like effect in the elevated plus-maze test.
运输条件
Room temperature or refrigerated transportation.
储存方式
Sealed and stored at 4℃，away from moisture
商品编号 规格 是否有货
PC14157-25mg 25mg In-Stock
PC14157-50mg 50mg In-Stock
