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【Medlife】(S)-(-)-Propranolol hydrochloride

发表时间:2024-05-27
中文名称 
(S)-(-)-Propranolol hydrochloride
中文别名 
(S)-盐酸普奈洛尔;(S)-(-)-普奈洛尔 盐酸盐;(S)-盐酸普萘洛尔;S型盐酸普奈洛尔;盐酸普奈洛尔;(s)-(-)-丙醇盐酸盐;S(-)-盐酸心得安
英文名称 
(S)-(-)-Propranolol hydrochloride
英文别名 
2-Propanol,1-[(1-methylethyl)amino]-3-(1-naphthalenyloxy)-, hydrochloride (1:1), (2S)-;(S)-(-)-PROPRANOLOL HYDROCHLORIDE;(S)-Propranolol Hydrochloride;dl-propranolol hcl;DL-PROPRANOLOL HYDROCHLORIDE;dl-propranololHClbp;dl-propranololhydrochloridebp;L-Propranololhydrochlorid;PENTAPROPANOLOLHYDROCHLORIDE;PROPANOLOL HYDROCHLORIDE;PROPRANOLOL HCL;Sazetidine A dihydrochloride;Levopropranolol hydrochloride;YP6GDU0L78;(S)-1-Isopropylamino-3-(1-naphthyloxy)-2-propanol hydrochloride;(2S)-1-naphthalen-1-yloxy-3-(propan-2-ylamino)propan-2-ol;hydrochloride;(2S)-1-(naphthalen-1-yloxy)-3-[(propan-2-yl)amino]propan-2-ol hydrochloride;C16H21NO2.HCl;(S)-1-(isopropylamino)-3-(naphthalen-1-yloxy)propan-2-ol hydrochloride;(2s)-1-(isopropylamino)-3-(1-naphthyloxy)pro
Cas No. 
4199-10-4
分子式 
C16H22ClNO2
分子量 
295.80
包装储存 
4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

生物活性 
(S)-(-)-Propranolol hydrochloride is a β-adrenergic receptor antagonist with log Kd values of -8.16, -9.08, and -6.93 for β1, β2, and β3, respectively. (S)-(-)-Propranolol hydrochloride the active enantiomer of propranolol and can be s used for study of hypertension, pheochromocytoma, myocardial infarction, cardiac arrhythmias, angina pectoris, and hypertrophic cardiomyopathy.
性状 
Solid
IC50 & Target[1][2] 
log Kd: -8.16 (β1-adrenergic receptor)
log Kd: -9.08 (β2-adrenergic receptor)
log Kd: -6.93 (β3-adrenergic receptor)
运输条件 
Room temperature or refrigerated transportation.
储存方式 
4°C, sealed storage, away from moisture
*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
参考文献 
[1]. Jillian G Baker , et al. The selectivity of beta-adrenoceptor antagonists at the human beta1, beta2 and beta3 adrenoceptors. Br J Pharmacol. 2005 Feb;144(3):317-22.  [Information]


本文来源:https://www.med-life.cn/

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