Cox-1 和 Cox-2抑制剂，(R)-(-)-Ibuprofen 是 Ibuprofen 的 R 型异构体，对 COX 无作用，可以抑制 NF-κB 的活化；(R)-(-)-Ibuprofen 具有抗炎和镇痛的作用。
中文名称
(R)-(-)-Ibuprofen
中文别名
R-布洛芬;(R)-(-)-布洛芬;(R)-布洛芬
英文名称
(R)-(-)-Ibuprofen
英文别名
Benzeneacetic acid, a-methyl-4-(2-methylpropyl)-, (aR)-;(R)-(-)-Ibuprofen;(R)-Ibuprofen;(R)-Ibuprofen;R-Ibuprofen;(-)-Ibuprofen;(2R)-2-(4-isobutylphenyl)propanoic acid;(2R)-2-(4-isobutylphenyl)-propanoic acid;alphaR-Sethyl-4-(2-methylpropyl)benzeneacetic acid;CHEBI:47835;R(-)-ibuprofen;R-(-)-p-Isobutylhydratropic acid;(alphaR)-alpha-Methyl-4-(2-methylpropyl)benzeneacetic acid;L-Ibuprofen;levibuprofen;(R)-2-(4-Isobutylphenyl)propanoic acid;(2R)-2-[4-(2-methylpropyl)phenyl]propanoic acid;(R)-alpha-methyl-4-(2-methylpropyl)benzeneacetic acid;99W8H60N62;Benzeneacetic acid, alpha-methyl-4-(2-methylpropyl)-, (R)-;(-)-Ibuprophen;IZP;(r)(-) ibup
Cas No.
51146-57-7
分子式
C13H18O2
分子量
206.28
包装储存
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
生物活性
(R)-(-)-Ibuprofen is the R enantiomer of Ibuprofen, inactive on COX, inhibits NF-κB activation; (R)-(-)-Ibuprofen exhibits anti-inflammatory and antinociceptive effects.
性状
Solid
IC50 & Target[1][2]
NF-κB
体外研究(In Vitro)
(R)-(-)-Ibuprofen is the R enantiomer of Ibuprofen, with no inhibitory effect on COX, but is involved in pathways of lipid metabolism and is incorporated into triglycerides along with endogenous fatty acids. (R)-(-)-Ibuprofen (1 μM) significantly reduces NF-κB activation and completely prevents NF-κB induction at 10 μM. (R)-(-)-Ibuprofen inhibits NF-κB luciferase activity with an IC50 of 121.8 μM, weaker than that of S(+)-ibuprofen (IC50, 61.7 μM). Furthermore, (R)-(-)-Ibuprofen (10 mM) has no effect on HSF.
Medlife has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件
Room temperature or refrigerated transportation.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
参考文献
[1]. Evans AM, et al. Comparative pharmacology of S(+)-ibuprofen and (RS)-ibuprofen. Clin Rheumatol. 2001 Nov;20 Suppl 1:S9-14. [Information]
[2]. Scheuren N, et al. Modulation of transcription factor NF-kappaB by enantiomers of the nonsteroidal drug ibuprofen. Br J Pharmacol. 1998 Feb;123(4):645-52. [Information]
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