中文名称
Norepinephrine hydrochloride
中文别名
(R)-(-)-去甲肾上腺素盐酸盐;去甲肾上腺素盐酸盐;盐酸去甲肾上腺素;L-去甲肾上腺素盐酸盐
英文名称
Norepinephrine hydrochloride
英文别名
(R)-4-(2-Amino-1-hydroxyethyl)benzene-1,2-diol hydrochloride;1,2-Benzenediol,4-[(1R)-2-amino-1-hydroxyethyl]-, hydrochloride (1:1);L-NORADRENALINE HYDROCHLORIDE;Noradrenaline hydrochloride;(-)-ARTERENOL HYDROCHLORIDE;(-)noradrenaline hydrochloride;(-)-norepinephrine hydrochloride;(R)-(-)-noradrenaline hydrochloride;[2-(3,4-dihydroxyphenyl)-2-hydroxy-ethyl]ammonium chloride;[2-(3,4-dihydroxyphenyl)-2-hydroxy-ethyl]azanium chloride;1-(3,4-dihydroxyphenyl)-2-aminoethanol hydrochloride;aktaminhydrochloride;L-ARTERENOL HYDROCHLORIDE;lev;L-NOREPINEPHRINE HYDROCHLORIDE;Norepinephrine hydrochloride
Cas No.
329-56-6
分子式
C8H11NO3.HCl
分子量
205.64
包装储存
4°C, sealed storage and away from moisture；*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage and away from moisture)；
生物活性
Norepinephrine (Levarterenol; L-Noradrenaline) hydrochloride is a potent adrenergic receptor (AR) agonist. Norepinephrine activates α1, α2, β1 receptors.
性状
Solid
IC50 & Target[1][2]
α1-adrenergic receptor
α2-adrenergic receptor
体外研究(In Vitro)
Norepinephrine (Levarterenol; L-Noradrenaline) hydrochloride is generally considered to be a β1-subtype selective adrenergic agonist over β2-adrenoceptor. Norepinephrine(NE) hydrochloride also has direct activity at the β2-adrenoceptor in higher concentrations.
Adipocytes from the inguinal fat pad (iWA) or the interscapular fat pad (BA) are isolated from neonatal wild-type C57BL/6J mice and cultured. To examine the effect of activating AT2 upon β-adrenergic signaling, cAMP production is first assessed in response to Norepinephrine (NE, 10 μM) with or without CGP (10 nM) co-treatment.
Norepinephrine (NE) increases cAMP as expected in iWA, and CGP does not alter this effect
Norepinephrine (NE) is also known to induce lipolysis, and liberated fatty acids are required to functionally activate UCP1 protein and to stimulate heat production.
运输条件
Room temperature or refrigerated transport.
储存方式
4°C, sealed storage and away from moisture；*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage and away from moisture)；
ClinicalTrial
结构分类
Alkaloids
Other A
来源
Plants
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