中文名称
(+)- Corydaline
中文别名
延胡索碱甲;2,3,9.10-四甲氧基-13Α-甲基-13ΑΒ-小檗因;延胡索碱;紫堇碱;紫菫鹼;(+)-紫堇碱,延胡索甲素;延胡索碱(紫堇块茎碱);延胡索甲素;WAKO036-14971榛子蛋白质标准品;延胡索甲素（标准品）;延胡索甲素（紫堇碱）;延胡索甲素对照品;延胡索碱甲Corydaline;紫堇;紫堇碱:(延胡索甲素:Corydaline);紫堇碱标准品;紫堇灵 Corydaline;延胡索甲素(紫堇碱,延胡索碱,(+)-紫堇碱,D-紫堇碱);延胡索甲素,紫堇碱;紫堇碱,延胡索碱甲,延胡索甲素
英文名称
(+)- Corydaline
英文别名
Corydaline;(13s-e)-thyl;2,3,9,10-tetramethoxy-13-alpha-methyl-13a-beta-berbin;2,3,9,10-tetramethoxy-13-methyl-berbin;6h-dibenzo(a,g)quinolizine,5,8,13,13a-tetrahydro-2,3,9,10-tetramethoxy-13-me;corydalin;(+) CORYDALINE;CORYDALINE, (+);(+)- Corydaline;(13S,13aR)-2,3,9,10-tetramethoxy-13-methyl-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinoline;Berbine,2,3,9,10-tetramethoxy-13-methyl;d-Corydalin;(+)-Corydaline;d-Corydaline;08N392L8VX
Cas No.
518-69-4
分子式
C22H27NO4
分子量
369.45
包装储存
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
生物活性
Corydaline ((+)-Corydaline), an isoquinoline alkaloid isolated from Corydalis yanhusuo, is an AChE inhibitor with an IC50 of 226 μM. Corydaline is a μ-opioid receptor (Ki of 1.23 μM) agonist and inhibits enterovirus 71 (EV71) replication (IC50 of 25.23 μM). Corydaline has anti-angiogenic, anti-allergic and gastric-emptying and antinociceptive activities.
性状
Solid
IC50 & Target[1][2]
AChE
μ *** Receptor/MOR
体外研究(In Vitro)
Corydaline (12.5-50 μM; 24 hours) treatment inhibits EV71 replication by suppressing the COX-2 expression and the phosphorylation of JNK MAPK and P38 MAPK but not ERK MAPK 体外研究.
Corydaline could inhibit the viral RNA synthesis in a dose dependent manner.
Medlife has not independently confirmed the accuracy of these methods. They are for reference only.
Western Blot Analysis
Cell Line: Vero cells infected with EV71
Concentration: 12.5 μM, 25 μM, 50 μM
Incubation Time: 24 hours
Result: Reduced the phosphorylation of P38 MAPK and JNK MAPK and the expression of COX-2.
体内研究(In Vivo)
Corydaline (10 mg/kg; subcutaneous administration; once) treatment shows antinociceptive effects in mice by significantly inhibiting the writhing behavior.
Medlife has not independently confirmed the accuracy of these methods. They are for reference only.
Animal Model: Male CD1 mice (30-35 g, 7-8 weeks old) injected with acetic acid
Dosage: 10 mg/kg
Administration: Subcutaneous administration; once
Result: Showed antinociceptive effects in mice.
运输条件
Room temperature or refrigerated transportation.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
结构分类
Alkaloids
Isoquinoline Alkaloids
来源
Plants
***aceae
Corydalis yanhusuo W. T. Wang
参考文献
[1]. Hai-Tao Xiao, et al. Acetylcholinesterase inhibitors from Corydalis yanhusuo. Nat Prod Res. 2011 Sep;25(15):1418-22. [Information]
[2]. Hui-Qiang Wang, et al. Corydaline inhibits enterovirus 71 replication by regulating COX-2 expression. J Asian Nat Prod Res. 2017 Nov;19(11):1124-1133. [Information]
[3]. Teresa Kaserer, et al. Identification and characterization of plant-derived alkaloids, corydine and corydaline, as novel mu opioid receptor agonists. Sci Rep. 2020 Aug 14;10(1):13804. [Information]
