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| 产地 | 中国 |
| 品牌 | PrimeGene（普欣） |
| 货号 | 101-11 |
| 用途 | 细胞/科研/抗肿瘤药物 |
| 包装规格 | 2μg |
| 纯度 | > 95 %% |
| CAS编号 | |
| 是否进口 | 否 |
产品名称：Recombinant Human Interleukin-11（rHuIL-11）
产品价格：
| 货号 | 规格 | 价格 |
| 101-11 | 2μg | 600 |
| 101-11 | 10μg | 1500 |
| 101-11 | 100μg | 9560 |
| 101-11 | 250μg | 17200 |
| 101-11 | 500μg | 22360 |
| 101-11 | 1mg | 30580 |
技术参数：
| Synonyms | AGIF |
| Accession | P20809 |
| GeneID | 3589 |
| Source | Escherichia coli. |
| Molecular Weight | Approximately 19.1 kDa, a single non-glycosylated polypeptide chain containing 179 amino acids. |
| Quantity | 2μg/10μg/1000μg |
| AA Sequence | MPGPPPGPPR VSPDPRAELD STVLLTRSLL ADTRQLAAQL RDKFPADGDH NLDSLPTLAM SAGALGALQL PGVLTRLRAD LLSYLRHVQW LRRAGGSSLK TLEPELGTLQ ARLDRLLRRL QLLMSRLALP QPPPDPPAPP LAPPSSAWGG IRAAHAILGG LHLTLDWAVR GLLLLKTRL |
| Purity | > 95 % by SDS-PAGE and HPLC analyses. |
| Biological Activity | Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using murine B9-11 cells is less than 1 ng/ml, corresponding to a specific activity of > 1.0 × 106 IU/mg. |
| Physical Appearance | Sterile Filtered White lyophilized (freeze-dried) powder. |
| Formulation | Lyophilized from a 0.2 μm filtered concentrated solution in PBS, pH 7.4. |
| Endotoxin | Less than 1 EU/μg of rHuIL-11 as determined by LAL method. |
| Reconstitution | We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1 % BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 °C. Further dilutions should be made in appropriate buffered solutions. |
| Stability & Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. - 12 months from date of receipt, -20 to -70 °C as supplied. - 1 month, 2 to 8 °C under sterile conditions after reconstitution. - 3 months, -20 to -70 °C under sterile conditions after reconstitution. |
| Usage | This material is offered by Shanghai PrimeGene Bio-Tech for research, laboratory or further evaluation purposes. NOT FOR HUMAN USE. |
| Reference | 1. McKinley D, Wu Q, Yang-Feng T, et al. 1992. Genomics. 13:814-9. 2. Paul SR, Bennett F, Calvetti JA, et al. 1990. Proc Natl Acad Sci U S A. 87:7512-6. 3. Barton VA, Hall MA, Hudson KR, et al. 2000. J Biol Chem. 275:36197-203. |
| Background | Interleukin-11 (IL-11) is encoded by the IL11 gene and is a member of IL-6 superfamily, distinguished based on their use of the common co-receptor gp130. It is a multifunctional cytokine first isolated from bone marrow-derived stromal cells. IL-11 receptor activation requires formation of a complex of two IL-11 molecules with two molecules of the ligand-binding IL-11Rα subunit and two molecules of the expressed cell signaling β subunit, gp130. The functions of IL-11 are that it directly stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells, and induces megakaryocyte maturation resulting in increased platelet production. |
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