产品名称：Recombinant Human Interleukin-15（rHuIL-15）

产品价格：

产品介绍：

Accession	P40933
GeneID	3600
Source	Escherichia coli.
Molecular Weight	Approximately 12.9 kDa, a single non-glycosylated polypeptide chain containing 114 amino acids.
Quantity	2μg/10μg/1000μg
AA Sequence	NWVNVISDLK KIEDLIQSMH IDATLYTESD VHPSCKVTAM KCFLLELQVI SLESGDASIH DTVENLIILA NNSLSSNGNV TESGCKECEE LEEKNIKEFL QSFVHIVQMF INTS
Purity	> 97 % by SDS-PAGE and HPLC analyses.
Biological Activity	Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using murine CTLL-2 cells is less than 0.5 ng/ml, corresponding to a specific activity of > 2.0 × 106 IU/mg.
Physical Appearance	Sterile Filtered White lyophilized (freeze-dried) powder.
Formulation	Lyophilized from a 0.2 μm filtered concentrated solution in PBS, pH 7.4.
Endotoxin	Less than 1 EU/μg of rHuIL-15 as determined by LAL method.
Reconstitution	We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1 % BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 °C. Further dilutions should be made in appropriate buffered solutions.
Stability & Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. - 12 months from date of receipt, -20 to -70 °C as supplied. - 1 month, 2 to 8 °C under sterile conditions after reconstitution. - 3 months, -20 to -70 °C under sterile conditions after reconstitution.
Usage	This material is offered by Shanghai PrimeGene Bio-Tech for research, laboratory or further evaluation purposes. NOT FOR HUMAN USE.
SDS-PAGE
Reference	1. Anderson DM, Johnson L, Glaccum MB, et al. 1995. Genomics, 25: 701-6. 2. Krause H, Jandrig B, Wernicke C, et al. 1996. Cytokine, 8: 667-74. 3. Chirifu M, Hayashi C, Nakamura T, et al. 2007. Nat Immunol, 8: 1001-7. 4. Grabstein KH, Eisenman J, Shanebeck K, et al. 1994. Science, 264: 965-8. 5. Giri JG, Ahdieh M, Eisenman J, et al. 1994. EMBO J, 13: 2822-30. 6. Arena A, Merendino RA, Bonina L, et al. 2000. New Microbiol, 23: 105-12.
Background	Human Interleukin-15 (IL-15) is expressed by the IL15 gene located on the chromosome 4. It shares approximately 97 % and 73 % sequence identity with simian and murine IL-15, respectively. Both human and simian IL-15 are active on murine cells. IL-15 is secreted by mononuclear phagocytes (and some other cells), especially macrophages following infection by virus. It possesses a variety of biological functions, including stimulating and maintaining of cellular immune responses, especially regulating T and natural killer (NK) cell activation and proliferation. In additionally, it shares many biological properties with IL-2, including T, B and NK cell-stimulatory activities. IL-15 signals through a complex composed of IL-2/IL-15 receptor beta chain. Although IL-15 lacks sequence homology with IL-2, it has recently been shown that both the beta and gamma chains of the IL-2 receptor are utilized for IL-15 binding and signaling. In addition, an IL-15 specific binding protein has also been cloned from a mouse T cell clone.

Primegene重组蛋白六大优势：

★高纯度、高蛋白活性

★低内毒素

★不同批次 产品稳定

★国内现货、高效快速

★Bio-Techne旗下品牌，品质保障

★无缝替代进口蛋白，质优价廉。

Primegene蛋白分装小贴士：

Primegene（普欣）是美国Bio-Techne（原R&D）旗下子品牌，专注于重组蛋白研发、生产， 产品涵盖分子生物学、蛋白化学、细胞生物学、免疫学等生命科学的诸多领域，拥有蛋白表达，菌种发酵，蛋白纯化，蛋白冻干以及抗体制备等完整的技术平台，并拥有自己的GMP中试生产车间。重组蛋白产品500多个，覆盖20余个物种及多项专利技术。

上海怡淼化学科技有限公司，作为美国Bio-Techne（原R&D）旗下子品牌Primegene（普欣）授权代理商，为抗肿瘤药物、细胞治疗、细胞培养、美容产品等领域的客户提供优质的产品和服务，同时可以提供：Perfemiker（博飞美科）、Sigma（西格玛）、Gibco、Jackson、TCI（梯希爱）、Alfa（阿法埃莎）、Acros、Thermo Fisher（赛默飞）等多种品牌，为您的科研提供一站式解决方案，欢迎咨询。