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| 产地 | 中国 |
| 品牌 | PrimeGene（普欣） |
| 货号 | 103-10 |
| 用途 | 细胞/科研/抗肿瘤药物 |
| 包装规格 | 5μg |
| 纯度 | > 98 %% |
| CAS编号 | |
| 是否进口 | 否 |
产品名称：Recombinant Human B-Cell Maturation Antigen/TNFRSF17（rHuBCMA）
产品价格：
| 货号 | 规格 | 价格 |
| 103-10 | 5μg | 600 |
| 103-10 | 20μg | 1490 |
| 103-10 | 100μg | 6250 |
| 103-10 | 250μg | 13380 |
| 103-10 | 500μg | 20640 |
| 103-10 | 1mg | 30580 |
产品介绍：
| Synonyms | TNFRSF17, BCM, CD269 |
| Accession | Q02223 |
| GeneID | 608 |
| Source | Escherichia coli. |
| Molecular Weight | Approximately 5.4 kDa, a single non-glycosylated polypeptide chain containing 50 amino acids. |
| Quantity | 5μg/20μg/1000μg |
| AA Sequence | AGQCSQNEYF DSLLHACIPC QLRCSSNTPP LTCQRYCNAS VTNSVKGTNA |
| Purity | > 98 % by SDS-PAGE and HPLC analyses. |
| Biological Activity | Fully biologically active when compared to standard. The ED50 as determined by its ability to inhibit APRIL-mediated proliferation of anti-IgM stimulated murine B cells is no less than 40 ng/ml, corresponding to a specific activity of > 2.5 × 104 IU/mg in the presence of 100 ng/ml human APRIL. |
| Physical Appearance | Sterile Filtered White lyophilized (freeze-dried) powder. |
| Formulation | Lyophilized from a 0.2 μm filtered concentrated solution in 30 % acetonitrile, 0.1 % TFA. |
| Endotoxin | Less than 1 EU/μg of rHuBCMA as determined by LAL method. |
| Reconstitution | We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1 % BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 °C. Further dilutions should be made in appropriate buffered solutions. |
| Stability & Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. - 12 months from date of receipt, -20 to -70 °C as supplied. - 1 month, 2 to 8 °C under sterile conditions after reconstitution. - 3 months, -20 to -70 °C under sterile conditions after reconstitution. |
| Usage | This material is offered by Shanghai PrimeGene Bio-Tech for research, laboratory or further evaluation purposes. NOT FOR HUMAN USE. |
| Reference | 1. Kim J, Gross JA, Dillon SR, et al. 2011. Autoimmunity, 44: 69-81. 2. Sun J, Feng J, Li Y, et al. 2006. Biochem Biophys Res Commun, 346: 1158-62. 3. Pelletier M, Thompson JS, Qian F, et al. 2003. J Biol Chem, 278: 33127-33. 4. Laabi Y, Gras MP, Brouet JC, et al. 1994. Nucleic Acids Res, 22: 1147-54. |
| Background | B-Cell Maturation Antigen (BCMA), encoded by the TNFRSF17 gene in humans. It is a member of the TNF receptor superfamily and a type III membrane protein containing one extracellular cysteine rich domain. It is expressed on mature B-cells and other B-cell lines. BCMA can binds to TNFSF13B/BLyS/BAFF and TNFSF13/APRIL, and has functions that promotes B-cell survival, plays a role in the regulation of humoral immunity, and activates NF-kappa-B and JNK BCMA. |
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