|
| 产地 | 中国 |
| 品牌 | PrimeGene（普欣） |
| 货号 | 104-23 |
| 用途 | 细胞/科研/抗肿瘤药物 |
| 包装规格 | 5μg |
| 纯度 | > 95 %% |
| CAS编号 | |
| 是否进口 | 否 |
产品名称：Recombinant Human Fibroblast Growth Factor 23（rHuFGF-23）
产品价格：
| 货号 | 规格 | 价格 |
| 104-23 | 5μg | 600 |
| 104-23 | 20μg | 1490 |
| 104-23 | 100μg | 5730 |
| 104-23 | 250μg | 10030 |
| 104-23 | 500μg | 15480 |
| 104-23 | 1mg | 22930 |
产品介绍：
| Accession | Q9GZV9 |
| GeneID | 8074 |
| Source | Escherichia coli. |
| Molecular Weight | Approximately 25.3 kDa, a single non-glycosylated polypeptide chain containing 227 amino acids. |
| Quantity | 5μg/20μg/1000μg |
| AA Sequence | YPNASPLLGS SWGGLIHLYT ATARNSYHLQ IHKNGHVDGA PHQTIYSALM IRSEDAGFVV ITGVMSRRYL CMDFRGNIFG SHYFDPENCR FQHQTLENGY DVYHSPQYHF LVSLGRAKRA FLPGMNPPPY SQFLSRRNEI PLIHFNTPIP RRHTRSAEDD SERDPLNVLK PRARMTPAPA SCSQELPSAE DNSPMASDPL GVVRGGRVNT HAGGTGPEGC RPFAKFI |
| Purity | > 95 % by SDS-PAGE and HPLC analyses. |
| Biological Activity | Fully biologically active when compared to standard. The ED50 as determined by thymidine uptake assay using FGF-receptors transfected BaF3 cells is less than 0.5 μg/ml, corresponding to a specific activity of > 2.0 × 103 IU/mg in the presence of 0.3 μg/ml of rMuKlotho and 10 μg/ml of heparin. |
| Physical Appearance | Sterile Filtered White lyophilized (freeze-dried) powder. |
| Formulation | Lyophilized from a 0.2 μm filtered concentrated solution in PBS, pH 7.4. |
| Endotoxin | Less than 1 EU/μg of rHuFGF-23 as determined by LAL method. |
| Reconstitution | We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1 % BSA to a concentration of 0.1-1.0 mg/ml. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 °C. Further dilutions should be made in appropriate buffered solutions. |
| Stability & Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. - 12 months from date of receipt, -20 to -70 °C as supplied. - 1 month, 2 to 8 °C under sterile conditions after reconstitution. - 3 months, -20 to -70 °C under sterile conditions after reconstitution. |
| Usage | This material is offered by Shanghai PrimeGene Bio-Tech for research, laboratory or further evaluation purposes. NOT FOR HUMAN USE. |
| Reference | 1. Smallwood PM, Munoz-Sanjuan I, Tong P, et al. 1996. Proc Natl Acad Sci U S A. 93:9850-7. 2. Fu L, John LM, Adams SH, et al. 2004. Endocrinology. 145:2594-603. 3. Kharitonenkov A, Shiyanova TL, Koester A, et al. 2005. J Clin Invest. 115:1627-35. 4. Kurosu H, Kuro OM. 2009. Mol Cell Endocrinol. 299:72-8. 5. Lin BC, Wang M, Blackmore C, et al. 2007. J Biol Chem. 282:27277-84. 6. Kharitonenkov A, Dunbar JD, Bina HA, et al. 2008. J Cell Physiol. 215:1-7. 7. Riminucci M, Collins MT, Fedarko NS, et al. 2003. J Clin Invest. 112:683-92. 8. Shimada T, Hasegawa H, Yamazaki Y, et al. 2004. J Bone Miner Res. 19:429-35. |
| Background | Human FGF-23 belongs to the FGF-19 subfamily which has three members FGF-19, 21, 23. All FGF family members are heparin binding growth factors with a core 120 amino acid (a.a.) FGF domain that allows for a common tertiary structure. They are classically considered to be paracrine factors and are known for their roles in tissue patterning and organogenesis during embryogenesis. By contrast, the FGF-19 subfamily has recently been shown to function in an endocrine manner. Members of this subfamily have poor ability of binding to heparin binding site which is a crucial factor in ligand-receptor complex formation. β-Klotho has been identified as co-factor required for FGF-19, 21, 23 signaling. It can obviously increase ligand-receptor affinity. FGF-23 is most highly expressed in bone, from which it circulates through the blood to regulate vitamin D and phosphate metabolism in kidney. |
★高纯度、高蛋白活性
★低内毒素
★不同批次 产品稳定
★国内现货、高效快速
★Bio-Techne旗下品牌，品质保障
★无缝替代进口蛋白，质优价廉。
上海怡淼化学科技有限公司，作为美国Bio-Techne（原R&D）旗下子品牌Primegene（普欣）授权代理商，为抗肿瘤药物、细胞治疗、细胞培养、美容产品等领域的客户提供优质的产品和服务，同时可以提供：Perfemiker（博飞美科）、Sigma（西格玛）、Gibco、Jackson、TCI（梯希爱）、Alfa（阿法埃莎）、Acros、Thermo Fisher（赛默飞）等多种品牌，为您的科研提供一站式解决方案，欢迎咨询。
更多产品信息，请联系客服咨询。
