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| 产地 | 中国 |
| 品牌 | PrimeGene（普欣） |
| 货号 | 106-05 |
| 用途 | 细胞/科研/抗肿瘤药物 |
| 包装规格 | 2μg |
| 纯度 | > 97 %% |
| CAS编号 | |
| 是否进口 | 否 |
产品名称：Recombinant Human Interferon-beta1b（rHuIFN-β1b）
产品价格：
| 货号 | 规格 | 价格 |
| 106-05 | 2μg | 600 |
| 106-05 | 10μg | 1490 |
| 106-05 | 100μg | 5730 |
| 106-05 | 250μg | 10030 |
| 106-05 | 500μg | 15480 |
| 106-05 | 1mg | 22930 |
产品介绍：
| Accession | P01574 |
| GeneID | 3456 |
| Source | Escherichia coli. |
| Molecular Weight | Approximately 20.0 kDa, a single non-glycosylated polypeptide chain containing 166 amino acids. |
| Quantity | 2μg/10μg/1000μg |
| AA Sequence | MSYNLLGFLQ RSSNFQCQKL LWQLNGRLEY CLKDRMNFDI PEEIKQLQQF QKEDAALTIY EMLQNIFAIF RQDSSSTGWN ETIVENLLAN VYHQINHLKT VLEEKLEKED FTRGKLMSSL HLKRYYGRIL HYLKAKEYSH CAWTIVRVEI LRNFYFINRL TGYLRN |
| Purity | > 97 % by SDS-PAGE and HPLC analyses. |
| Biological Activity | Fully biologically active when compared to standard. The specific activity determined by an anti-viral assay is no less than 3.0 × 107 IU/mg. |
| Physical Appearance | Sterile Filtered White lyophilized (freeze-dried) powder. |
| Formulation | Lyophilized from a 0.2 μm filtered concentrated solution in PBS, pH 7.4, containing 2 % HSA and 3 % mannitol. |
| Endotoxin | Less than 1 EU/μg of rHuIFN-β1b as determined by LAL method. |
| Reconstitution | We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1 % BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 °C. Further dilutions should be made in appropriate buffered solutions. |
| Stability & Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. - 12 months from date of receipt, -20 to -70 °C as supplied. - 1 month, 2 to 8 °C under sterile conditions after reconstitution. - 3 months, -20 to -70 °C under sterile conditions after reconstitution. |
| Usage | This material is offered by Shanghai PrimeGene Bio-Tech for research, laboratory or further evaluation purposes. NOT FOR HUMAN USE. |
| Reference | 1. Yoshino A, Tashiro S, Ogino A, et al. 2011. Int J Oncol, 39: 529-42. 2. Farrell RA, Marta M, Gaeguta AJ, et al. 2012. Rheumatology (Oxford), 51: 590-9. 3. Breckpot K, Corthals J, Bonehill A, et al. 2005. J Leukoc Biol, 78: 898-908. 4. Oger J, Francis G, Chang P. 2005. J Neurol Sci, 237: 45-52. 5. Giorelli M, Livrea P, Trojano M. 2005. J Interferon Cytokine Res, 25: 395-406. |
| Background | IFN-βs are proteins produced by many cell types including lymphocytes (NK cells, B-cells and T-cells), macrophages, fibroblasts, endothelial cells, osteoblasts and others. They have antiviral activity that it is mainly involved in innate immune response. The IFN-β family has 2 subtypes，which are IFN-β1 (IFNB1) and IFN-β3 (IFNB3) (a gene designated IFN-β2 is actually IL-6). IFN-β1 is used as a treatment for multiple sclerosis as it reduces the relapse rate. |
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