1、产品物理参数：
|
常用名 |
N-[4-[(6,7-二甲氧基-4-喹啉基)氧基]-2-甲氧基苯基]-N'-[1-(2-噻唑基)乙基]脲 |
英文名 |
Ki20227 |
|
CAS号 |
623142-96-1 |
分子量 |
480.536 |
|
密度 |
1.3±0.1 g/cm3 |
沸点 |
621.8±55.0 °C at 760 mmHg |
|
分子式 |
C24H24N4O5S |
熔点 |
无资料 |
|
闪点 |
329.8±31.5 °C |
|
|
Ki-20227是CSF1R抑制剂，IC50为2 nM，对VEGFR2的IC50为12 nM，对c-Kit/PDGFRβ的IC50则为451/217 nM。
|
描述 |
Ki-20227是CSF1R抑制剂，IC50为2 nM，对VEGFR2的IC50为12 nM，对c-Kit/PDGFRβ的IC50则为451/217 nM。 |
|
相关类别 |
信号通路 >> 蛋白酪氨酸激酶 >> c-FMS 研究领域 >> 炎症/免疫 |
|
参考文献 |
[1]. Ohno H, et al. A c-fms tyrosine kinase inhibitor, Ki20227, suppresses osteoclast differentiation and osteolytic bone destruction in a bone metastasis model. Mol Cancer Ther. 2006 Nov;5(11):2634-43. [2]. Ohno H, et al. The orally-active and selective c-Fms tyrosine kinase inhibitor Ki20227 inhibits disease progression in a collagen-induced arthritis mouse model. Eur J Immunol. 2008 Jan;38(1):283-91. [3]. Uemura Y, et al. The selective M-CSF receptor tyrosine kinase inhibitor Ki20227 suppresses experimental autoimmune encephalomyelitis. J Neuroimmunol. 2008 Mar;195(1-2):73-80. [4]. Boru Hou, et al. Ki20227 influences the morphology of microglia and neurons through inhibition of CSF1R during global ischemia. Int J Clin Exp Pathol. 2016;9(12):12459-12469. |
|
密度 |
1.3±0.1 g/cm3 |
|
沸点 |
621.8±55.0 °C at 760 mmHg |
|
分子式 |
C24H24N4O5S |
|
分子量 |
480.536 |
|
闪点 |
329.8±31.5 °C |
|
精确质量 |
480.146729 |
|
PSA |
132.07000 |
|
LogP |
4.18 |
|
蒸汽压 |
0.0±1.8 mmHg at 25°C |
|
折射率 |
1.651 |
|
1-{4-[(6,7-Dimethoxy-4-quinolinyl)oxy]-2-methoxyphenyl}-3-[1-(1,3-thiazol-2-yl)ethyl]urea |
|
hms3244k11 |
|
hms3244l11 |
|
hms3244k12 |
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Urea, N-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]-2-methoxyphenyl]-N'-[1-(2-thiazolyl)ethyl]- |
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N-(4-((6,7-dimethoxy-4-quinolyl)oxy)-2-methoxyphenyl)-N'-(1-(1,3-thiazole-2-yl)ethyl)urea |
|
Ki20227 |
