[Medlife优选]Paricalcitol
发表时间：2024-07-31
中文名称
[优选]Paricalcitol
中文别名
帕立骨化醇;帕立骨化醇 USP标准品;帕立骨化醇-D6;帕立骨化醇标准品;帕立骨化醇（冷藏运输）;帕里醇;1,25-双羟基维他命D2
英文名称
Paricalcitol
英文别名
Paricalcitol;Zemplar;(1R,3R)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(E,2R,5S)-6-Hydroxy-5,6-dimethylhept-3-en-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]cyclohexane-1,3-diol;19-Nor-1alpha,25-dihydroxyvitamin D2;Paracalcin;(1α,3β,7E,22E)-19-Nor-9,10-secoergosta-5,7,22-triene-1,3,25-triol solution;(1α, 3β, 7E,22E)-19-Nor-9,10-secoergosta-5,7,22-triene-1,3,25-triol;Paricalcitol(Zemplar);19-Nor-1,25- dihydroxyvitaMin D2;1α,25-Dihydroxy-19-nor-vitaMin D2;1,25-DihydroxyvitaMin D2 Paricalcitol;Paricalcitol (10 mg) (COLD SHIPMENT REQUIRED)
Cas No.
131918-61-1
分子式
C27H44O3
分子量
416.64
包装储存
4°C, protect from light, stored under nitrogen
*该产品在溶液状态不稳定，建议您现用现配，即刻使用。
生物活性
Paricalcitol, a vitamin D analogue, is a vitamin D receptor agonist, used for the prevention and treatment of secondary hyperparathyroidism (excessive secretion of parathyroid hormone) associated with chronic renal failure.
性状
Solid
体外研究(In Vitro)
Paricalcitol (3×10 M; HP + PC) produces a significant reduction in calcification relative to the observed in cells in HP medium. Paricalcitol causes a reduction in the levels of nuclear β-catenin to a level similar to that observed in control cells.
Medlife has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)
Paricalcitol (300 ng/kg/day) significantly decreases Tau, and prevents LV dysfunction in mice. Paricalcitol reduces mRNA expression of ANP, fibronectin and collagen III in the TAC-pari mice.
Medlife has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件
Room temperature or refrigerated transportation.
储存方式
4°C, protect from light, stored under nitrogen
*该产品在溶液状态不稳定，建议您现用现配，即刻使用。
ClinicalTrial
参考文献
[1]. Martinez-Moreno JM, et al. In vascular smooth muscle cells paricalcitol prevents phosphate-induced Wnt/beta-catenin activation. Am J Physiol Renal Physiol. 2012 Aug 8. [Information]
[2]. Meems LM, et al. The vitamin D receptor activator paricalcitol prevents fibrosis and diastolic dysfunction in a murine model of pressure overload. J Steroid Biochem Mol Biol. 2012 Jul 16;132(3-5):282-289. [Information]
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