[Medlife优选]Xanthurenic acid
发表时间：2024-07-31
II型mGlu受体活化剂，Xanthurenic acid 在下丘脑的感觉传输过程中，被认为是 Group II 代谢型谷氨酸受体 的激动剂。
中文名称
[优选]Xanthurenic acid
中文别名
4,8-二羟基喹啉-2-甲酸;黄尿酸;4,8-二羟基-2-喹啉甲酸;Xanthurenic Acid 黄尿酸;黃尿酸;4,8-二羟基喹啉-2-羧酸;4,8-二羥-2-喹啉甲酸;4.8二羟基喹啉甲酸;4,8-二羟基喹啉甲酸
英文名称
4,8-Dihydroxyquinoline-2-carboxylic acid
英文别名
4,8-Dihydroxyquinoline-2-carboxylic acid;Xanthurenic acid;4,8-Dihydroxyquinaldic acid;4,8-dihydroxy-2-Quinolinecarboxylic acid;8-hydroxy-4-oxo-1H-quinoline-2-carboxylic acid;XANTHURENIC ACID(RG);4,8-Dihydroxyquinoline-2-carboxylic Acid
Cas No.
59-00-7
分子式
C10H7NO4
分子量
205.17
生物活性
Xanthurenic acid is a putative endogenous Group II metabotropic glutamate receptor agonist, on sensory transmission in the thalamus.
性状
Solid
IC50 & Target[1][2]
Human Endogenous Metabolite
mGluR2
mGluR3
体内研究(In Vivo)
Xanthurenic acid is a putative endogenous Group II metabotropic glutamate receptor agonist, on sensory transmission in the thalamus. The inhibition of Xanthurenic acid (XA) on sensory can be found when applied iontophoretically and i.v., is similar to that of other Group II mGlu receptor agonists in reducing inhibition evoked in the VB from the thalamic reticular nucleus upon physiological sensory stimulation. Furthermore, it is postulated that Xanthurenic acid may be the first potential endogenous allosteric agonist for the mGlu receptors. As the Group II receptors and kynurenine metabolism pathway have both been heavily implicated in the pathophysiology of schizophrenia, Xanthurenic acid could play a pivotal role in antipsychotic research as this potential endocoid represents both a convergence within these two biological parameters and a novel class of Group II mGlu receptor ligand.
Medlife has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件
Room temperature or refrigerated transportation.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
结构分类
Phenols
Monophenols
Ketones, Aldehydes, Acids
参考文献
[1]. Copeland CS, et al. Actions of Xanthurenic acid, a putative endogenous Group II metabotropic glutamate receptor agonist, on sensory transmission in the thalamus. Neuropharmacology. 2013 Mar;66:133-42. [Information]
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