208.19
生物活性
(S)-MCPG ((+)-MCPG) is a potent group I/II metabotropic glutamate receptor (mGluRs) antagonist and the active isomer of (RS)-MCPG (HY-100371). (S)-MCPG can be used for the study of the function of mGluRs in spatial learning.
性状
Solid
IC50 & Target[1][2]
mGluR
体外研究(In Vitro)
(S)-MCPG (100 μM) has no detectable effects on basal spine formation or elimination mechanisms in WT slice cultures. (S)-MCPG prevents the increase in spine turnover triggered by TBS and interferes with the mechanisms of activity-dependent spine stabilization in Hippocampal slice cultures.
Medlife has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)
MCPG (intraventricular injection; 20 μg) treated rat are slower to learn the task and takes longer to reach the platform than vehicle injected animals. On days 2 and 3, MCPG rats has a significant longer escape latency and the measure of search error is significantly longer on each of the first 3 days. On day 4, MCPG-treated animals reaches the same level of performance as control animals in Morris water maze.
Medlife has not independently confirmed the accuracy of these methods. They are for reference only.
Animal Model: Male Lister-Hooded rats in the learning of the Morris water maze
Dosage: 20 μg
Administration: Intraventricular injection; 20 μg; 4 days
Result: Impaired the performance of rats in the spatial version of the Morris water maze, but 1/10 of this dose did not.
运输条件
Room temperature or refrigerated transportation.
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