细胞色素P450（CYP）同种型CYP2C19的底物，(S)-Mephenytoin is an anticonvulsive drug which is metabolized by N-demethylation and 4-hydroxylation (of the aromatic ring). (S)-Mephenytoin is a substrate of the cytochrome P450 (CYP) isoform CYP2C19, also known as mephenytoin
中文名称
(S)-Mephenytoin
中文别名
(S)-美芬妥因;(S)-(＋)-美芬妥英;(S)-美芬妥英;S-美芬妥英;甲秦皮素
英文名称
(S)-Mephenytoin
英文别名
2,4-Imidazolidinedione,5-ethyl-3-methyl-5-phenyl-, (5S)-;(S)-Mephenytoin;(S)-5-Ethyl-3-methyl-5-phenylimidazolidine-2,4-dione;(+)-Mephobarbital;(+)-Mephobarbitol;(5R)-mephobarbital;(S)-5-Ethyl-1-methyl-5-phenyl-2,4,6(1H,3H,5H)-pyrimidinetrione;(S)-Methylphenobarbital;[14C]-(+)-Mephenytoin;2,4,6(1H,3H,5H)-Pyrimidinetrione,5-ethyl-1-methyl-5-phenyl-,(S);S(+)-5-Ethyl-1-methyl-5-phenylbarbituric acid;S(+)-5-Ethyl-3-methyl-5-phenylhydantoin;S-mephenytoin;UNII-5NC67NU76B component ALARQZQTBTVLJV-ZDUSSCGKSA-N;(S)-(+)-5-Ethyl-3-methyl-5-phenyl-2,4-imidazolidinedione;(S)-(+)-5-Ethyl-3-methyl-5-phenylhydantoin
Cas No.
70989-04-7
分子式
C12N2O2H14
分子量
218.25
生物活性
(S)-Mephenytoin ((+)-Mephenytoin) is an anticonvulsive agent. (S)-Mephenytoin is a substrate of the cytochrome P450 (CYP) isoform CYP2C19. (S)-Mephenytoin can be used for the analysis of cytochrome P450 metabolism.
性状
Solid
IC50 & Target[1][2]
CYP2
体外研究(In Vitro)
In the presence of cytochrome b5, the Km for S-mephenytoin is 1.25 mM with all five purified cytochrome P-450s preparations.
Medlife has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件
Room temperature or refrigerated transportation.
产品订购：https://www.med-life.cn/
Medlife，致力于提供高品质、高性价比小分子化合物的产品。
Medlife小分子化合物大量库存，提供超过2万种的抑制剂、激动剂、拮抗剂等产品，是药物及疾病研究的重要原料供应商。
